The US remains Vietnam’s largest seafood export destination, with annual export values ranging between 1.5 billion and 2.1 billion USD, over the past five years. Therefore, economic and political changes in the market will affect Vietnam’s aquatic shipments. According to the Vietnam Association of Seafood Exporters and Producers, amidst the ongoing US-China trade tensions, US importers are actively seeking alternative seafood sources, and Vietnam is well-positioned to fill this gap due to its improving product quality, and reputation in shrimp and pangasius exports. However, Vietnamese exporters should remain cautious about anti-dumping and anti-subsidy taxes, as well as stringent trade barriers in the US market, which could lead to fiercer competition. Additionally, rigorous quality standards, set by the US Food and Drug Administration, require firms to strictly comply with sustainable production, and food safety protocols. US consumers are placing greater emphasis on sustainability, environmental protection, and social responsibility. Vietnamese firms should comply with international standards, and ensure transparency in their production processes and the origin of raw materials, to gain customers’ trust, experts recommended./.